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@AnirbanM I feel like we have had this conversation before... Sure Alphafold can predict protein structure but, the most important and interesting parts of protein are highly flexible and do not exist in one conformation. Many proteins exist as complexes with other protiens. The structure of protein by itself and in a complex is significantly different due to protein-protein interactions. In case of drug design and discovery, the protein structure is perturbed by binding of drugs and is different compared to protein alone. So, basically this structure prediction platform is a great tool (for example to design protein constructs) to help in getting to experimentally determining structures.